https://www.ceesdekker.net - An Overview
https://www.ceesdekker.net - An Overview
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‘The next is nanopores, and that is our oldest line of investigation and which has now triggered DNA sequencers according to nanopores. We pull individual DNA strands via a nanopore and might then go through from the nucleotide sequence. Incredibly not too long ago, we even managed to read out just one protein for the first time applying This method. But this line of study is not merely about acquiring tools, but additionally about real Organic thoughts.
Human Rad51 filaments on double- and solitary-stranded DNA: correlating regular and irregular sorts with recombination functionality.
Multicolor imaging in the bacterial nucleoid and mobile division proteins with blue, orange, and in the vicinity of-infrared fluorescent proteins
Sculpting nano-electrodes using a transmission electron beam for electrical and geometrical characterization of nanoparticles.
That may be a aspiration of mine and we set to operate using a scrumptious dose of naivety. This can be something that will most likely produce magnificent ends in the more time time period, but that doesn't matter. You should not only want to operate on the concerns of tomorrow, but will also about the queries with the day just after tomorrow.’
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes
What distinguishes biology from chemistry is usually that these factors jointly make up a residing procedure. The secret of claimed life, I think, lies while in the interactions, the interplay of All those molecules. The big problem with regard to the origin of existence remains unanswered. How did we ever evolve from basic molecules into your really advanced units we see currently? We do not know. I need to operate on These types of huge, open concerns.’
Nanopores represent an elegant and versatile tool to evaluate one molecules. We investigate novel detection modes with good-point out nanopores cees dekker together with several solutions to evaluate proteins with nanopores. Assignments encompass the next:
2003, demonstrated the very first biosensors produced outside of a carbon nanotube; fixed the framework and mechanism of DNA repair proteins; and discovery of a new system for fabricating stable-condition nanopores for DNA translocation
Bulk-surface area coupling identifies the mechanistic link concerning Min-protein styles in vivo As well as in vitro
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Nanoscientist Cees Dekker is undoubtedly an amiable and flamboyant gentleman who appears much young in comparison to the sixty two many years he actually is – modern glasses, psychedelic shirt, engaging smile – although not one particular to waste time. He takes his time, but not more than required.
2008, initially observation of protein-coated DNA translocation by nanopores; solved the origin on the electrophoretic pressure on DNA in nanopores; identified a major velocity boost of microtubules in electric fields; found an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid
2013, managed shaping of Dwell bacterial cells into arbitrary shapes; and discovery of spontaneous fluctuations while in the handedness of histone tetrasomes